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Amifostine trihydrate

CAS No. 112901-68-5

Amifostine trihydrate ( —— )

产品货号. M17831 CAS No. 112901-68-5

氨磷汀是第一种批准的放射防护化合物,用于降低顺铂治疗引起的肾脏问题的风险。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥405 有现货
10MG ¥527 有现货
25MG ¥956 有现货
100MG ¥2187 有现货
200MG ¥3499 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Amifostine trihydrate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    氨磷汀是第一种批准的放射防护化合物,用于降低顺铂治疗引起的肾脏问题的风险。
  • 产品描述
    Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
  • 体外实验
    Amifostine (0.78125-100?μM, 24 h)trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM.
  • 体内实验
    Amifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice. Animal Model:Male C57BL/6 mice with myocardial I/R injury Dosage:400 mg/kg Administration: Intravenous injection; 4 hours Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    112901-68-5
  • 分子量
    268.27
  • 分子式
    C5H15N2O3PS·3H2O
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?H2O : 125 mg/mL (465.95 mM)
  • SMILES
    O.O.O.NCCCNCCSP(O)(O)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Tas S, Ozkul F, Arik MK, Kiraz A, Vural A.Acta Cir Bras. 2016 Mar;31(3):156-60.
产品手册
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