Amifostine trihydrate
CAS No. 112901-68-5
Amifostine trihydrate ( —— )
产品货号. M17831 CAS No. 112901-68-5
氨磷汀是第一种批准的放射防护化合物,用于降低顺铂治疗引起的肾脏问题的风险。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥405 | 有现货 |
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10MG | ¥527 | 有现货 |
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25MG | ¥956 | 有现货 |
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100MG | ¥2187 | 有现货 |
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200MG | ¥3499 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Amifostine trihydrate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述氨磷汀是第一种批准的放射防护化合物,用于降低顺铂治疗引起的肾脏问题的风险。
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产品描述Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
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体外实验Amifostine (0.78125-100?μM, 24 h)trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM.
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体内实验Amifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice. Animal Model:Male C57BL/6 mice with myocardial I/R injury Dosage:400 mg/kg Administration: Intravenous injection; 4 hours Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域Others-Field
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适应症——
化学信息
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CAS Number112901-68-5
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分子量268.27
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分子式C5H15N2O3PS·3H2O
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 125 mg/mL (465.95 mM)
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SMILESO.O.O.NCCCNCCSP(O)(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tas S, Ozkul F, Arik MK, Kiraz A, Vural A.Acta Cir Bras. 2016 Mar;31(3):156-60.
产品手册
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